I think the only reason people talk about that is some 2S oils don't mix well. I recently started using Castrol 2T snowmobile (yup, went the other way with synthetic), and you could see it form a layer with the Poo VES oil I'd been running when I first poured it in. I've never heard of mixing oils and having some reaction between them, but some still suggest running the tank down to 1/4 or so. I can't say I see even a reason for that: as long as it gets oil, it doesn't matter if it's the old stuff, new stuff, or a mix of the two.