I've sat and pondered this very question for a good amount of time.
I'm sure its do able. It'll take some engineering to acomplish it though.
The dpm is a great little system. Uses "negative pressure" like you stated. Now, i've never experimented or tried anything, yet. Once my turbo build comes to life I will, but I dont know if it will happen this year or not.
Anyway, Dpm simply modulates subtraction of fuel by lowering pressure (suction) in the fuel bowl. It cant add to the jet thats there. Only subtract. (perfect fail safe too)
The issue i see is taking it from a vacuum system to a pressurized system is that the low pressure area in the venturi isnt any longer driven by air flow through the carb. The main driving force becomes added pressure. True there will still be the siphon effect, but the carb has to be pressureized much higher now in relationship to the air flow.
I think..............
Heck just try it. Hook up the Air box vent of the dpm directly to manifold pressure. See what happens.
One thought I had was to utilize the voltage refrence of the DPM somehow.
I just thumbed through the manual,
"using pre defined maps, the ecm is constantly activating (duty cycle) the dpm solenoid to optimize the air/fuel mixture"
"Ecm recives different signals........yada yada..... which indicate operating conditions at Millisecond intervals."
(most important part) "the engine RPM (though trigger coils) and TPS are the primary sensors. Other sensors (air pressure (located on the ecm itself) air and coolant temp) are used as secondary sensors."
"3D map is used to maintain Air/fuel at optimum."
"The Ecm begins to lean fuel mixture when engine RPM is above aprox. 3500."
All the above bits are from the 09' shop book. There has to be a way to make it do what we want.
Thoughts? I plan on testing this theory one of these days.